Insertion of cytoplasmic tyrosine sequences into the nonphagocytic receptor Fc gamma RIIB establishes phagocytic function
نویسندگان
چکیده
منابع مشابه
Insertion of cytoplasmic tyrosine sequences into the nonphagocytic receptor Fc gamma RIIB establishes phagocytic function.
Receptors for the Fc domain of IgG on cells of hematopoietic lineage perform important functions, including stimulation of the ingestion of IgG-coated cells. In examining the function of Fc gamma receptor isoforms by transfection into COS-1 cells, we have observed that Fc gamma RIIA induces the binding and phagocytosis of IgG-sensitized RBCs (EA) and that transfected COS-1 cells can serve as a ...
متن کاملInduction of phagocytosis by a protein tyrosine kinase.
The transmission of extracellular signals to cellular targets by many noncatalytic surface receptors is dependent on interaction between cytoplasmic protein tyrosine kinases (PTKs) and tyrosine-containing sequences in the cytoplasmic domain of the receptor or an associated subunit. Isoforms of each of the three classes of the noncatalytic Fc gamma receptors, Fc gamma RI, Fc gamma RII, and Fc ga...
متن کاملInsertion of a gamma-continuous function
A necessary and sufficient condition in terms of lower cut sets are given for the insertion of a $gamma-$continuous function between two comparable real-valued functions.
متن کاملRole of oligosaccharide residues of IgG1-Fc in Fc gamma RIIb binding.
Engagement of Fc gamma receptors (Fc gamma Rs) with the Fc region of IgG elicits immune responses by leukocytes. The recent crystal structure of Fc gamma RIII in complex with IgG-Fc has provided details of molecular interactions between these components (Sondermann, P., Huber, R., Oosthuizen, V., and Jacob, U. (2000) Nature 406, 267-273). One of the most intriguing issues is that glycosylation ...
متن کاملInhibition of Fc g Receptor - Mediated Phagocytosis by a Nonphagocytic Fc g Receptor
There are three major classes of human Fcg receptors (FcgRI, FcgRII, and FcgRIII) and various isoforms of each class are capable of mediating phagocytosis. FcgRIIA is an unusual Fcg receptor in that it transmits a phagocytic signal in the absence of an additional receptor subunit. The cytoplasmic domain of FcgRIIA contains a conserved motif containing two copies of the sequence YXXL. The tyrosi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 1994
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v83.8.2072.2072